Definition. An intrinsic renal state is a condition in which kidney damage has occurred but not due to lack of adequate kidney blood flow (a prerenal state) or obstruction of urine outflow (a postrenal state). As with both prerenal and postrenal conditions, an intrinsic renal state will eventually lead to a loss of GFR. Diabetes is the leading cause of kidney failure, accounting for 44% percent of new cases. Current research suggests that control of high blood pressure is a key factor in slowing this disease. Strict control of blood sugar levels and reduction of dietary protein intake are also important. Treatment to prevent diabetic kidney disease should begin early — before kidney damage develops. In the YyfG6T.

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